摘要
本设计任务是年产3000吨肌苷的全厂设计。肌苷是一种代谢调控型初级代谢产物,是机体内ATP、辅酶A、核糖核苷酸和脱氧核糖核苷酸的组成部分,参与机体内的核酸代谢,能量代谢以及蛋白质的合成,它在食品和医药领域起着重要作用,肌苷是食品中的呈味物,同时也是各种调味食品的营养助鲜剂;肌苷具有刺激细胞、增强细胞代谢等功能,能预防及解除由血防药物引起的对心脏或肝脏的副作用。近年来随着肌苷应用范围不断扩大,市场需求与日俱增,对肌苷进行工厂建设将具有十分广阔的前景。此次工厂设计为发酵法年产3000吨肌苷,以供应市场需求。微生物发酵法生产肌苷的成本较低,对环境无污染且效益较高等优点,是目前生产肌苷普遍采用的方法,并且用离子交换法和超滤法提取肌苷。本设计以枯草芽孢杆菌为生产菌株,选育高产的工业化生产菌种,获得与生产菌株相匹配的最佳培养基配方和发酵工艺条件。在本设计中,论述了肌苷生产的工艺流程,计算了发酵车间和提取车间的物料衡算以及能量衡算,并且对主要设备进行了计算与选型,绘制了发酵罐结构图、发酵工艺流程图、发酵车间摆布图以及全厂设备摆布图,完成设计说明书。
关键词:肌苷;发酵;提取;全厂设计
ABSTRACT
The desig
n task is to desig
n the factory with a
n a
n
nual productio
n of 3000 to
ns of i
nosi
ne. I
nosi
ne is a product of metabolism type primary metabolism, is the part of compositio
n the body of ATP, coe
nzyme A, RNA a
nd DNA, participate i
n
nucleic acid metabolism, e
nergy metabolism a
nd protei
n sy
nthesis i
n the body. It plays a
n importa
nt role i
n the field of food a
nd medici
ne, i
nosi
ne is flavor substa
nces i
n food, at the same time is also a variety of seaso
ni
ng food
nutritio
n a
nd fresh age
nt. I
nosi
ne have the fu
nctio
n of stimulated cells, e
nha
nce cell metabolism a
nd so o
n, ca
n preve
nt a
nd lift which caused by schistosomiasis a
nd the drugs to the heart or liver side effects. I
n rece
nt years, with the i
ncreasi
ng applicatio
n of i
nosi
ne, growi
ng market dema
nd, factory co
nstructio
n of i
nosi
ne will have very broad prospects. This desig
n is a
n a
n
nual productio
n of 3000 to
ns of i
nosi
ne ferme
ntatio
n method to supply market dema
nd. Use microbial ferme
ntatio
n productio
n i
nosi
ne have the adva
ntage of low cost,
no pollutio
n to the e
nviro
nme
nt a
nd higher efficie
ncy. Is the method curre
ntly used to produce i
nosi
ne, a
nd use io
n excha
nge method a
nd ultrafiltratio
n method to extractio
n i
nosi
ne. The desig
n of Bacillus subtilis as the productio
n strai
n, selective breedi
ng of high yield i
ndustrialized produci
ng strai
ns, to obtai
n the best culture medium formula a
nd ferme
ntatio
n co
nditio
ns. I
n this desig
n, discusses the process of i
nosi
ne productio
n, calculatio
n of the material bala
nce a
nd e
nergy bala
nce i
n the ferme
ntatio
n workshop a
nd the extractio
n workshop was calculated, a
nd calculatio
n a
nd selectio
n of mai
n equipme
nt are also carried out, structure diagram of ferme
ntatio
n ta
nk was draw
n, flow chart of ferme
ntatio
n process, co
ntrol chart of ferme
ntatio
n workshop a
nd the whole pla
nt equipme
nt to complete the desig
n specificatio
n. Key word: i
nosi
ne; ferme
ntatio
n; extract; whole pla
nt desig
n 目录 第一章前言1 第一节肌苷的概述1 第二节肌苷生产的工艺流程4 第三节厂址选择和工厂总平面设计6 第四节可行性研究结论6 第二章肌苷生产的工艺论证7 第一节菌种的扩大培养7 第二节发酵工艺的控制要点9 第三节其它辅助工艺10 第四节工艺论证13 第三章全厂物料衡算及能量衡算16 第一节设计参数16 第二节物料衡算16 第三节能量衡算19 第四章发酵车间计算及设备选型23 第一节发酵罐的计算及选型23 第二节种子罐的计算及选型31 第三节补料罐的计算及选型36 第四节氨水储罐的计算与选型37 第五节空气压缩机的计算与选型38 第六节液体输送设备计算及选型38 第五章提取车间计算及设备选型39 第一节提取段物料衡算及选型39 参考文献 致谢 第一章前言 第一节肌苷的概述 一、引言 肌苷(I
nosi
ne)是一种代谢调控型初级代谢产物,为腺嘌呤前体物质,是机体内ATP、辅酶A、核糖核苷酸和脱氧核糖核苷酸的组成部分,参与机体内的核酸代谢,能量代谢以及蛋白质的合成。它能提高机体ATP的水平,可转化为多种核苷酸。肌苷对细胞膜具有良好的通透性,能透过细胞膜进入体细胞,进而转变为核苷酸,再变成ATP参与代谢,有促进肝细胞恢复,防止脂肪肝的作用,并能提高各种酶的活性,刺激机体产生抗体。肌苷具有刺激细胞、增强细胞代谢等功能,能预防及解除由血防药物引起的对心脏或肝脏的副作用[1]。同时也是食品中的呈味物,目前世界上已有不少国家以肌苷酸的含量作为衡量食品新鲜程度的特征指标之一[2][3]。
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n task is to desig
n the factory with a
n a
n
nual productio
n of 3000 to
ns of i
nosi
ne. I
nosi
ne is a product of metabolism type primary metabolism, is the part of compositio
n the body of ATP, coe
nzyme A, RNA a
nd DNA, participate i
n
nucleic acid metabolism, e
nergy metabolism a
nd protei
n sy
nthesis i
n the body. It plays a
n importa
nt role i
n the field of food a
nd medici
ne, i
nosi
ne is flavor substa
nces i
n food, at the same time is also a variety of seaso
ni
ng food
nutritio
n a
nd fresh age
nt. I
nosi
ne have the fu
nctio
n of stimulated cells, e
nha
nce cell metabolism a
nd so o
n, ca
n preve
nt a
nd lift which caused by schistosomiasis a
nd the drugs to the heart or liver side effects. I
n rece
nt years, with the i
ncreasi
ng applicatio
n of i
nosi
ne, growi
ng market dema
nd, factory co
nstructio
n of i
nosi
ne will have very broad prospects. This desig
n is a
n a
n
nual productio
n of 3000 to
ns of i
nosi
ne ferme
ntatio
n method to supply market dema
nd. Use microbial ferme
ntatio
n productio
n i
nosi
ne have the adva
ntage of low cost,
no pollutio
n to the e
nviro
nme
nt a
nd higher efficie
ncy. Is the method curre
ntly used to produce i
nosi
ne, a
nd use io
n excha
nge method a
nd ultrafiltratio
n method to extractio
n i
nosi
ne. The desig
n of Bacillus subtilis as the productio
n strai
n, selective breedi
ng of high yield i
ndustrialized produci
ng strai
ns, to obtai
n the best culture medium formula a
nd ferme
ntatio
n co
nditio
ns. I
n this desig
n, discusses the process of i
nosi
ne productio
n, calculatio
n of the material bala
nce a
nd e
nergy bala
nce i
n the ferme
ntatio
n workshop a
nd the extractio
n workshop was calculated, a
nd calculatio
n a
nd selectio
n of mai
n equipme
nt are also carried out, structure diagram of ferme
ntatio
n ta
nk was draw
n, flow chart of ferme
ntatio
n process, co
ntrol chart of ferme
ntatio
n workshop a
nd the whole pla
nt equipme
nt to complete the desig
n specificatio
n. Key word: i
nosi
ne; ferme
ntatio
n; extract; whole pla
nt desig
n 目录 第一章前言1 第一节肌苷的概述1 第二节肌苷生产的工艺流程4 第三节厂址选择和工厂总平面设计6 第四节可行性研究结论6 第二章肌苷生产的工艺论证7 第一节菌种的扩大培养7 第二节发酵工艺的控制要点9 第三节其它辅助工艺10 第四节工艺论证13 第三章全厂物料衡算及能量衡算16 第一节设计参数16 第二节物料衡算16 第三节能量衡算19 第四章发酵车间计算及设备选型23 第一节发酵罐的计算及选型23 第二节种子罐的计算及选型31 第三节补料罐的计算及选型36 第四节氨水储罐的计算与选型37 第五节空气压缩机的计算与选型38 第六节液体输送设备计算及选型38 第五章提取车间计算及设备选型39 第一节提取段物料衡算及选型39 参考文献 致谢 第一章前言 第一节肌苷的概述 一、引言 肌苷(I
nosi
ne)是一种代谢调控型初级代谢产物,为腺嘌呤前体物质,是机体内ATP、辅酶A、核糖核苷酸和脱氧核糖核苷酸的组成部分,参与机体内的核酸代谢,能量代谢以及蛋白质的合成。它能提高机体ATP的水平,可转化为多种核苷酸。肌苷对细胞膜具有良好的通透性,能透过细胞膜进入体细胞,进而转变为核苷酸,再变成ATP参与代谢,有促进肝细胞恢复,防止脂肪肝的作用,并能提高各种酶的活性,刺激机体产生抗体。肌苷具有刺激细胞、增强细胞代谢等功能,能预防及解除由血防药物引起的对心脏或肝脏的副作用[1]。同时也是食品中的呈味物,目前世界上已有不少国家以肌苷酸的含量作为衡量食品新鲜程度的特征指标之一[2][3]。
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